Nano-Structured Lipid Carrier-Based Oral Glutathione Formulation Mediates Renoprotection against Cyclophosphamide-Induced Nephrotoxicity, and Improves Oral Bioavailability of Glutathione Confirmed through RP-HPLC Micellar Liquid Chromatography

Nano-Structured Lipid Carrier-Based Oral Glutathione Formulation Mediates Renoprotection against Cyclophosphamide-Induced Nephrotoxicity, and Improves Oral Bioavailability of Glutathione Confirmed through RP-HPLC Micellar Liquid Chromatography

The study aimed to develop a new glutathione (GSH) oral formulation to enhance the delivery of GSH and counter the nephrotoxicity of the anticancer drug, cyclophosphamide (CP). A nanostructured lipid carrier glutathione formulation (GSH-NLCs) composed of glutathione (500 mg), stearic and oleic acid...

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Bibliographic Details
Main Authors: Adel M. Ahmad, Hamdoon A. Mohammed, Tarek M. Faris, Abeer S. Hassan, Hebatallah B. Mohamed, Mahmoud I. El Dosoky, Esam M. Aboubakr
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
cyclophosphamide
anticancer
acrolein
renal toxicity
glutathione
nanostructured lipid carrier
Online Access:https://www.mdpi.com/1420-3049/26/24/7491

Internet

https://www.mdpi.com/1420-3049/26/24/7491

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