Overexpression of Hsp104 by Causing Dissolution of the Prion Seeds Cures the Yeast [<i>PSI<sup>+</sup></i>] Prion

Overexpression of Hsp104 by Causing Dissolution of the Prion Seeds Cures the Yeast [<i>PSI<sup>+</sup></i>] Prion

The yeast Sup35 protein misfolds into the infectious [<i>PSI<sup>+</sup></i>] prion, which is then propagated by the severing activity of the molecular chaperone, Hsp104. Unlike other yeast prions, this prion is unique in that it is efficiently cured by the overexpression as...

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Bibliographic Details
Main Authors: Katherine E. Stanford, Xiaohong Zhao, Nathan Kim, Daniel C. Masison, Lois E. Greene
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
prion
yeast
curing
Hsp104
overexpression
trimming
Online Access:https://www.mdpi.com/1422-0067/24/13/10833

Internet

https://www.mdpi.com/1422-0067/24/13/10833

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