Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate

Evidence of a New Crystalline Phase of Prednisolone Obtained from the Study of the Hydration–Dehydration Mechanisms of the Sesquihydrate

The dehydration of prednisolone sesquihydrate is studied and characterized by different physico-chemical analysis methods. The meticulous study of this dehydration led to the highlighting of a new solid form (form 3), metastable, never identified before. In a second step, the rehydration of anhydrou...

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Bibliographic Details
Main Authors: Aurélien Lemercier, Nicolas Couvrat, Yohann Cartigny, Morgane Sanselme, Yohann Corvis, Philippe Espeau, Gérard Coquerel
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
prednisolone
sesquihydrate
polymorphism
isomorphous dehydrate
hydration
dehydration
Online Access:https://www.mdpi.com/1999-4923/15/6/1694

Internet

https://www.mdpi.com/1999-4923/15/6/1694

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