The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain.

Cold allodynia is a common feature of neuropathic pain however the underlying mechanisms of this enhanced sensitivity to cold are not known. Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified and proposed to be molecular sensors for cold. Here we have inves...

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Bibliographic Details
Main Authors: Ombretta Caspani, Sandra Zurborg, Dominika Labuz, Paul A Heppenstall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2753652?pdf=render