Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse

Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse

IntroductionIn mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain (IgH) locus under control of its 3’ cis-regulatory region (3’RR). The 3’RR is itself transcribed and can undergo “locus suicide recombinati...

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Bibliographic Details
Main Authors: Nicolas Denis-Lagache, Christelle Oblet, Tiffany Marchiol, Audrey Baylet, Ophélie Têteau, Iman Dalloul, Zeinab Dalloul, Lina Zawil, Ophélie Dézé, Jeanne Cook-Moreau, Alexis Saintamand, Hend Boutouil, Ahmed Amine Khamlichi, Claire Carrion, Sophie Péron, Sandrine Le Noir, Brice Laffleur, Michel Cogné
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
antibody
immunoglobulin
lymphocyte
enhancer
recombination
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155906/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155906/full

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