Intron-Encoded Domain of Herstatin, An Autoinhibitor of Human Epidermal Growth Factor Receptors, Is Intrinsically Disordered

Intron-Encoded Domain of Herstatin, An Autoinhibitor of Human Epidermal Growth Factor Receptors, Is Intrinsically Disordered

Human epidermal growth factor receptors (HER/ERBB) form dimers that promote cell proliferation, migration, and differentiation, but overexpression of HER proteins results in cancer. Consequently, inhibitors of HER dimerization may function as effective antitumor drugs. An alternatively spliced varia...

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Bibliographic Details
Main Authors: Daisuke Tashiro, Shunji Suetaka, Nao Sato, Koji Ooka, Tomoko Kunihara, Hisashi Kudo, Junichi Inatomi, Yuuki Hayashi, Munehito Arai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
human epidermal growth factor receptor
herstatin
intron-encoded protein
intrinsically disordered protein
pre-molten globule state
small-angle X-ray scattering
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.862910/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.862910/full

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