Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines

Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines

Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine (LPC) acyltransferase (LPCAT) activities. It has been associated with tumor progression and cancer metastasis, but the mechanisms involved are no...

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Bibliographic Details
Main Authors: Daniel J. Lagal, María J. López-Grueso, José R. Pedrajas, Thomas L. Leto, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
redoxins
lipid peroxidation
mitochondrial dysfunction
GSK3β
epithelial–mesenchymal transition (EMT)
Online Access:https://www.mdpi.com/2076-3921/12/6/1153

Internet

https://www.mdpi.com/2076-3921/12/6/1153

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