Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines
Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine (LPC) acyltransferase (LPCAT) activities. It has been associated with tumor progression and cancer metastasis, but the mechanisms involved are no...
Main Authors: | Daniel J. Lagal, María J. López-Grueso, José R. Pedrajas, Thomas L. Leto, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-05-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/12/6/1153 |
Similar Items
-
Thioredoxin Downregulation Enhances Sorafenib Effects in Hepatocarcinoma Cells
by: María José López-Grueso, et al.
Published: (2019-10-01) -
NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity
by: Daniel J. Lagal, et al.
Published: (2023-12-01) -
Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells
by: María José López-Grueso, et al.
Published: (2020-10-01) -
Reduced exploratory behavior in neuronal nucleoredoxin knockout mice
by: Bao Ngoc Tran, et al.
Published: (2021-09-01) -
Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway
by: Zheng Q, et al.
Published: (2020-09-01)