Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

IntroductionDanger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma pati...

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Bibliographic Details
Main Authors: Guus P. Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J. Scheffer, Peter Pickkers, Matthijs Kox
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
danger-associated molecular patterns
high mobility group box 1
immune suppression
HLA-DR
postoperative infections
cytoreductive surgery
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00663/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00663/full

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