A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA
Familial Mediterranean fever (FMF) is the most common autoinflammatory disease associated with mutations in the MEFV gene encoding Pyrin. MEFV mutations are frequent in the Mediterranean region. Increased resistance to an infection endemic to this area could have caused a selective advantage for ind...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
South Kazakhstan Medical Academy
2020-08-01
|
| Series: | Central Asian Journal of Medical Hypotheses and Ethics |
| Subjects: | |
| Online Access: | https://cajmhe.com/index.php/journal/article/view/7 |
| _version_ | 1818924791272308736 |
|---|---|
| author | Ezgi Deniz Batu |
| author_facet | Ezgi Deniz Batu |
| author_sort | Ezgi Deniz Batu |
| collection | DOAJ |
| description | Familial Mediterranean fever (FMF) is the most common autoinflammatory disease associated with mutations in the MEFV gene encoding Pyrin. MEFV mutations are frequent in the Mediterranean region. Increased resistance to an infection endemic to this area could have caused a selective advantage for individuals with MEFV mutations. Recent studies have shown that Pyrin is a part of host defense against microorganisms and it gets activated after sensing Rho GTPase inactivation by bacteria such as Clostridium difficile or Yersinia pestis. However, Yersinia species have another effector molecule, YopM which inhibits Pyrin in addition to RhoA modifiers YopE and YopT. Continuously overactive Pyrin in individuals with MEFV mutations could be a good host defense against Yersinia infections. Y. pestis causes plague, which led to a devastating pandemic in the Mediterranean basin. Thus, plague could be the infection which caused a selective biologic advantage for MEFV mutation carriers in this area. |
| first_indexed | 2024-12-20T02:30:56Z |
| format | Article |
| id | doaj.art-1398d3bcb34e49cbbd897d592fad2794 |
| institution | Directory Open Access Journal |
| issn | 2708-9800 |
| language | English |
| last_indexed | 2024-12-20T02:30:56Z |
| publishDate | 2020-08-01 |
| publisher | South Kazakhstan Medical Academy |
| record_format | Article |
| series | Central Asian Journal of Medical Hypotheses and Ethics |
| spelling | doaj.art-1398d3bcb34e49cbbd897d592fad27942022-12-21T19:56:34ZengSouth Kazakhstan Medical AcademyCentral Asian Journal of Medical Hypotheses and Ethics2708-98002020-08-0111555910.47316/cajmhe.2020.1.1.077A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREAEzgi Deniz Batu0Department of Pediatrics, Division of Rheumatology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, TurkeyFamilial Mediterranean fever (FMF) is the most common autoinflammatory disease associated with mutations in the MEFV gene encoding Pyrin. MEFV mutations are frequent in the Mediterranean region. Increased resistance to an infection endemic to this area could have caused a selective advantage for individuals with MEFV mutations. Recent studies have shown that Pyrin is a part of host defense against microorganisms and it gets activated after sensing Rho GTPase inactivation by bacteria such as Clostridium difficile or Yersinia pestis. However, Yersinia species have another effector molecule, YopM which inhibits Pyrin in addition to RhoA modifiers YopE and YopT. Continuously overactive Pyrin in individuals with MEFV mutations could be a good host defense against Yersinia infections. Y. pestis causes plague, which led to a devastating pandemic in the Mediterranean basin. Thus, plague could be the infection which caused a selective biologic advantage for MEFV mutation carriers in this area.https://cajmhe.com/index.php/journal/article/view/7familial mediterranean feverplaguemissense mutationhypothesis |
| spellingShingle | Ezgi Deniz Batu A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA Central Asian Journal of Medical Hypotheses and Ethics familial mediterranean fever plague missense mutation hypothesis |
| title | A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA |
| title_full | A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA |
| title_fullStr | A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA |
| title_full_unstemmed | A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA |
| title_short | A HYPOTHETICAL ROLE FOR PLAGUE IN THE SELECTION OF MEFV MUTATION CARRIERS IN THE MEDITERRANEAN AREA |
| title_sort | hypothetical role for plague in the selection of mefv mutation carriers in the mediterranean area |
| topic | familial mediterranean fever plague missense mutation hypothesis |
| url | https://cajmhe.com/index.php/journal/article/view/7 |
| work_keys_str_mv | AT ezgidenizbatu ahypotheticalroleforplagueintheselectionofmefvmutationcarriersinthemediterraneanarea AT ezgidenizbatu hypotheticalroleforplagueintheselectionofmefvmutationcarriersinthemediterraneanarea |