A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

Transcription factors play a determining role in lineage commitment and cell differentiation. Interferon regulatory factor 8 (IRF8) is a lineage determining transcription factor in hematopoiesis and master regulator of dendritic cells (DC), an important immune cell for immunity and tolerance. IRF8 i...

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Bibliographic Details
Main Authors: Huaming Xu, Zhijian Li, Chao-Chung Kuo, Katrin Götz, Thomas Look, Marcelo AS de Toledo, Kristin Seré, Ivan G Costa, Martin Zenke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
interferon regulatory factor 8
dendritic cell
enhancer
lncRNA
feedback loop
CRISPR
Online Access:https://elifesciences.org/articles/83342

Internet

https://elifesciences.org/articles/83342

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