The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium

The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium

Neutrophil extracellular traps (NETs) fight endometritis, and elastase (ELA), a protease found in NETs, might induce collagen type I (COL1) accumulation in equine endometrium. Metallopeptidases (MMPs) are involved in extracellular matrix balance. The aim was to evaluate the effects of ELA and sivele...

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Bibliographic Details
Main Authors: Ana Amaral, Carina Fernandes, Maria Rosa Rebordão, Anna Szóstek-Mioduchowska, Karolina Lukasik, Barbara Gawronska-Kozak, Luís Telo da Gama, Dariusz J. Skarzynski, Graça Ferreira-Dias
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Animals
Subjects:
endometrosis
mare
elastase
sivelestat
collagen
metallopeptidases
Online Access:https://www.mdpi.com/2076-2615/10/5/863

Internet

https://www.mdpi.com/2076-2615/10/5/863

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