Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion

Herpes simplex virus (HSV) requires four essential virion glycoproteins—gD, gH, gL, and gB—for virus entry and cell fusion. To initiate fusion, the receptor binding protein gD interacts with one of two major cell receptors, HVEM or nectin-1. Once gD binds to a receptor, fusion is carried out by the...

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Bibliographic Details
Main Authors: Doina Atanasiu, Wan Ting Saw, Tina M. Cairns, Harvey M. Friedman, Roselyn J. Eisenberg, Gary H. Cohen
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
HSV
glycoproteins
protein–protein interactions
conformational changes
antibodies
Online Access:https://www.mdpi.com/1999-4915/15/4/895

Internet

https://www.mdpi.com/1999-4915/15/4/895

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