Intra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats

Intra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats

Abstract Our objective in this study is to determine whether intra-articular injection of miRNA-1 can attenuate the progression of OA in rats by down regulating Ihh. Knee chondrocytes were isolated from male Sprague–Dawley rats aged 2–3 days. Second-generation chondrocytes were transfected with miR-...

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Bibliographic Details
Main Authors: Pengcui Li, Yangyang Gao, Raorao Zhou, Xianda Che, Hang Wang, Lingling Cong, Pinpin Jiang, Dan Liang, Penghua Li, Chunfang Wang, Wenjin Li, Shengbo Sang, Qianqian Duan, Xiaochun Wei
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
MicroRNA-1
Intra-articular injection
Osteoarthritis
Indian hedgehog
Online Access:https://doi.org/10.1038/s41598-024-56200-4

Internet

https://doi.org/10.1038/s41598-024-56200-4

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