Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental fu...

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Bibliographic Details
Main Authors: Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude, Johanna Lepeule
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medicine
Subjects:
Placenta
DNA methylation
Blood pressure
Pregnancy
Cell-type heterogeneity
Mesenchymal stromal cells
Online Access:https://doi.org/10.1186/s12916-022-02610-y

Internet

https://doi.org/10.1186/s12916-022-02610-y

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