Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity

Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity

Background: The SARS-CoV-2 spike protein mediates attachment of the virus to the host cell receptor and fusion between the virus and the cell membrane. The S1 subunit of the spike glycoprotein (S1 protein) contains the angiotensin converting enzyme 2 (ACE2) receptor binding domain. The SARS-CoV-2 va...

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Bibliographic Details
Main Authors: Mizanur Rahman, Martin Irmler, Sandeep Keshavan, Micol Introna, Johannes Beckers, Lena Palmberg, Gunnar Johanson, Koustav Ganguly, Swapna Upadhyay
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
COVID-19
coronavirus
SARS-CoV-2
spike protein
SARS (severe acute respiratory syndrome)
MERS (middle east respiratory syndrome)
Online Access:https://www.mdpi.com/1999-4915/13/12/2537

Internet

https://www.mdpi.com/1999-4915/13/12/2537

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