NiH-catalyzed anti-Markovnikov hydroamidation of unactivated alkenes with 1,4,2-dioxazol-5-ones for the direct synthesis of N-alkyl amides

NiH-catalyzed anti-Markovnikov hydroamidation of unactivated alkenes with 1,4,2-dioxazol-5-ones for the direct synthesis of N-alkyl amides

Hydroamidation of unactivated alkenes is an efficient way to introduce nitrogen-based functional groups to alkenes, however the regioselectivity requires directing groups. Here, the authors report the ligand-controlled NiH-catalyzed anti-Markovnikov intermolecular hydroamidation of unactivated alken...

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Bibliographic Details
Main Authors: Bingnan Du, Chun-Ming Chan, Yuxin Ouyang, Kalok Chan, Zhenyang Lin, Wing-Yiu Yu
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00791-4

Internet

https://doi.org/10.1038/s42004-022-00791-4

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