Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 month...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2020-03-01
Schriftenreihe:Journal of Lipid Research
Schlagworte:
animal models
farnesylation
nuclear lamins
fluorescence microscopy
lipodystrophies
zinc metallopeptidase STE24
Online Zugang:http://www.sciencedirect.com/science/article/pii/S0022227520435242

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http://www.sciencedirect.com/science/article/pii/S0022227520435242

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