Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with an overall 5-year survival rate of 10%. Disease lethality is due to late diagnosis, early metastasis and resistance to therapy, including immunotherapy. PDA creates a robust fibroinflammatory tumor microenvironment that contributes t...

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Bibliographic Details
Main Authors: Zoe C. Schmiechen, Ingunn M. Stromnes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
PD-1
PD-L1
pancreatic ductal adenocarcinoma
T cell
exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.613815/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.613815/full

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