Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig
Abstract.: T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319306620 |
| _version_ | 1819112372522975232 |
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| author | Hitoshi Maekawa Takeshi Matsunobu Yasushi Satoh Takaomi Kurioka Asako Nakamura Noboru Iwakami Akihiro Shiotani |
| author_facet | Hitoshi Maekawa Takeshi Matsunobu Yasushi Satoh Takaomi Kurioka Asako Nakamura Noboru Iwakami Akihiro Shiotani |
| author_sort | Hitoshi Maekawa |
| collection | DOAJ |
| description | Abstract.: T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure–induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity. Keywords:: T-817MA, inner ear barotrauma, free radical |
| first_indexed | 2024-12-22T04:12:28Z |
| format | Article |
| id | doaj.art-13b13027d100418dbb5d7067b350620a |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T04:12:28Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-13b13027d100418dbb5d7067b350620a2022-12-21T18:39:29ZengElsevierJournal of Pharmacological Sciences1347-86132011-01-0111716770Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea PigHitoshi Maekawa0Takeshi Matsunobu1Yasushi Satoh2Takaomi Kurioka3Asako Nakamura4Noboru Iwakami5Akihiro Shiotani6Department of Otolaryngology, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanDepartment of Otolaryngology, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan; Corresponding author. takeshim@ndmc.ac.jpDepartment of Anesthesiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanDepartment of Otolaryngology, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanResearch Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimo-okui, Toyama 930-8508, JapanResearch Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimo-okui, Toyama 930-8508, JapanDepartment of Otolaryngology, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanAbstract.: T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure–induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity. Keywords:: T-817MA, inner ear barotrauma, free radicalhttp://www.sciencedirect.com/science/article/pii/S1347861319306620 |
| spellingShingle | Hitoshi Maekawa Takeshi Matsunobu Yasushi Satoh Takaomi Kurioka Asako Nakamura Noboru Iwakami Akihiro Shiotani Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig Journal of Pharmacological Sciences |
| title | Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig |
| title_full | Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig |
| title_fullStr | Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig |
| title_full_unstemmed | Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig |
| title_short | Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig |
| title_sort | protective effect of neurotrophic agent t 817ma against inner ear barotrauma in the guinea pig |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319306620 |
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