Palbociclib Induces Senescence in Melanoma and Breast Cancer Cells and Leads to Additive Growth Arrest in Combination With Irradiation

Palbociclib Induces Senescence in Melanoma and Breast Cancer Cells and Leads to Additive Growth Arrest in Combination With Irradiation

IntroductionSeveral kinase inhibitors (KI) bear the potential to act as radiosensitizers. Little is known of the radiosensitizing effects of a wide range of other KI like palbociclib, which is approved in ER+/HER2- metastatic breast cancer.MethodIn our study, we used healthy donor fibroblasts and br...

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Bibliographic Details
Main Authors: Tina Jost, Lucie Heinzerling, Rainer Fietkau, Markus Hecht, Luitpold V. Distel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
senescence
kinase inhibitor
radiotherapy
palbociclib
breast cancer
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.740002/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.740002/full

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