Novel GTF2I–PDGFRB and IKZF1–TYW1 fusions in pediatric leukemia with normal karyotype

Novel GTF2I–PDGFRB and IKZF1–TYW1 fusions in pediatric leukemia with normal karyotype

Abstract Background Many cases of acute lymphoblastic leukemia (ALL) carry visible acquired chromosomal changes of pathogenetic, diagnostic, and prognostic importance. Nevertheless, from one-fourth to half of newly diagnosed ALL patients have no visible chromosomal changes detectable by G-banding an...

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Bibliographic Details
Main Authors: Ioannis Panagopoulos, Marta Brunetti, Margrethe Stoltenberg, Rønnaug A. U. Strandabø, Julie Staurseth, Kristin Andersen, Ilyá Kostolomov, Tarjei S. Hveem, Susanne Lorenz, Tove Anita Nystad, Trond Flægstad, Francesca Micci, Sverre Heim
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Experimental Hematology & Oncology
Subjects:
Pediatric acute lymphoblastic leukemia
Normal karyotype
Submicroscopic deletions
Fusion genes
GTF2I–PDGFRB
Fluorescence in situ hybridization
Online Access:http://link.springer.com/article/10.1186/s40164-019-0136-y

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http://link.springer.com/article/10.1186/s40164-019-0136-y

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