Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma

Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma

A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the SC cell function. We propose Angpt-1 mimetic nanopar...

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Bibliographic Details
Main Authors: Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer, Miriam Breunig
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
glaucoma
POAG
Schlemm’s canal
Tie2
angiopoietin 1
Angpt-1 mimetic
Online Access:https://www.mdpi.com/1424-8247/15/1/18

Internet

https://www.mdpi.com/1424-8247/15/1/18

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