Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE

Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE

Background: Hyperfunctional platelets play important roles in thromboembolism in patients with β-thalassaemia/ haemoglobin E (β-thal/HbE). Our previous study revealed ex vivo inhibitory effects of deferiprone on normal platelets. Herein, we aimed to investigate the in vivo effects on platelets in pa...

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Bibliographic Details
Main Authors: Ngan Thi Tran, Pranee Sutcharitchan, Jindaporn Janprasit, Ponlapat Rojnuckarin, Noppawan Phumala Morales, Rataya Luechapudiporn
Format: Article
Language:English
Published: BioExcel Publishing Ltd 2022-12-01
Series:Drugs in Context
Subjects:
arachidonic acid
deferiprone
iron overload
platelet aggregation
p-selectin
thalassaemia
Online Access:https://www.drugsincontext.com/deferiprone-an-iron-chelator-alleviates-plateletbrhyperactivity-in-patients-with-%ce%b2-thalassaemia-hb-e/

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https://www.drugsincontext.com/deferiprone-an-iron-chelator-alleviates-plateletbrhyperactivity-in-patients-with-%ce%b2-thalassaemia-hb-e/

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