Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE

Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE

Background: Hyperfunctional platelets play important roles in thromboembolism in patients with β-thalassaemia/ haemoglobin E (β-thal/HbE). Our previous study revealed ex vivo inhibitory effects of deferiprone on normal platelets. Herein, we aimed to investigate the in vivo effects on platelets in pa...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Ngan Thi Tran, Pranee Sutcharitchan, Jindaporn Janprasit, Ponlapat Rojnuckarin, Noppawan Phumala Morales, Rataya Luechapudiporn
Format: Artikel
Sprache:English
Veröffentlicht: BioExcel Publishing Ltd 2022-12-01
Schriftenreihe:Drugs in Context
Schlagworte:
arachidonic acid
deferiprone
iron overload
platelet aggregation
p-selectin
thalassaemia
Online Zugang:https://www.drugsincontext.com/deferiprone-an-iron-chelator-alleviates-plateletbrhyperactivity-in-patients-with-%ce%b2-thalassaemia-hb-e/

Online

https://www.drugsincontext.com/deferiprone-an-iron-chelator-alleviates-plateletbrhyperactivity-in-patients-with-%ce%b2-thalassaemia-hb-e/

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