Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca2+-transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response. In the sarcoplasmic reticulum membrane, PLN binds to the sarco(endo)plasmic reticulum Ca2+-ATPase...

Full description

Bibliographic Details
Main Authors: Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David D Thomas, Alfonso De Simone, Gianluigi Veglia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
topological allostery
membrane proteins
oriented solid
state NMR
Online Access:https://elifesciences.org/articles/66226

Internet

https://elifesciences.org/articles/66226

Similar Items