Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2–1.4. However, the underlying action mechanis...

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Bibliographic Details
Main Authors: Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun, Zeng Xiongzhi
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
JZTX-V
kv4.3
mutants
molecular determinants
electrophysiological assays
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2053420

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2022.2053420

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