Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2–1.4. However, the underlying action mechanis...

Full description

Bibliographic Details
Main Authors: Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun, Zeng Xiongzhi
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
JZTX-V
kv4.3
mutants
molecular determinants
electrophysiological assays
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2053420

Similar Items

Similar Items