Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway

Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway

Atherosclerosis is a chronic inflammatory disease, occurring preferentially in bifurcation, branching, and bending of blood vessels exposed to disturbed flow. Disturbed flow in atheroprone areas activates elevated proteases, degrading elastin lamellae and collagenous matrix, resulting in endothelial...

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Bibliographic Details
Main Authors: Fei Fang, Tang Feng, Jianwei Li, Huaiyi Zhang, Qin Wang, Yidan Chen, Guixue Wang, Yang Shen, Xiaoheng Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-03-01
Series:Genes and Diseases
Subjects:
Atherosclerosis
Cathepsin K
Disturbed flow
Integrin
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222000964

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http://www.sciencedirect.com/science/article/pii/S2352304222000964

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