An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of <i>Trypanosoma brucei</i> Has a Surface Localization and Is Essential for Proliferation

An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of <i>Trypanosoma brucei</i> Has a Surface Localization and Is Essential for Proliferation

<i>Trypanosoma brucei</i> is the causative agent of African trypanosomiasis, a deadly disease that affects humans and cattle. There are very few drugs to treat it, and there is evidence of mounting resistance, raising the need for new drug development. Here, we report the presence of a p...

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Bibliographic Details
Main Authors: Núria W. Negrão, Logan P. Crowe, Brian S. Mantilla, Rodrigo P. Baptista, Sharon King-Keller, Guozhong Huang, Roberto Docampo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pathogens
Subjects:
Phospholipase C
plasma membrane
RNA interference
<i>Trypanosoma brucei</i>
Online Access:https://www.mdpi.com/2076-0817/12/3/386

Internet

https://www.mdpi.com/2076-0817/12/3/386

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