Modulation of Cellular NAD<sup>+</sup> Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps

Modulation of Cellular NAD<sup>+</sup> Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps

Cancer-associated thrombosis is the second-leading cause of mortality in patients with cancer and presents a poor prognosis, with a lack of effective treatment strategies. NAD(P)H quinone oxidoreductase 1 (NQO1) increases the cellular nicotinamide adenine dinucleotide (NAD<sup>+</sup>) l...

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Bibliographic Details
Main Authors: Wa Cao, Meng-Yu Zhu, Seung-Hoon Lee, Su-Bin Lee, Hyung-Jin Kim, Byung-Ouk Park, Cheol-Hwan Yoon, Dipendra Khadka, Gi-Su Oh, Hyeok Shim, Tae-Hwan Kwak, Hong-Seob So
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
cancer-associated thrombosis
NAD<sup>+</sup>
dunnione
tissue factor
NETs
Online Access:https://www.mdpi.com/1422-0067/22/21/12085

Internet

https://www.mdpi.com/1422-0067/22/21/12085

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