A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury

A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury

Abstract Background Traumatic brain injury (TBI) is characterized by a primary mechanical injury and a secondary injury associated with neuroinflammation, blood–brain barrier (BBB) disruption and neurodegeneration. We have developed a novel cannabidiol aminoquinone derivative, VCE-004.8, which is a...

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Bibliographic Details
Main Authors: Carmen Navarrete, Adela García-Martín, Alejandro Correa-Sáez, María E. Prados, Francisco Fernández, Rafael Pineda, Massimiliano Mazzone, Marina Álvarez-Benito, Marco A. Calzado, Eduardo Muñoz
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Neuroinflammation
Subjects:
Traumatic brain injury
Protein phosphatase 2A
Hypoxia-inducible factor
Prolyl-hydroxylases
Brain–blood barrier
Neuroprotection
Online Access:https://doi.org/10.1186/s12974-022-02540-9

Internet

https://doi.org/10.1186/s12974-022-02540-9

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