Differential fibril morphologies and thermostability determine functional roles of Staphylococcus aureus PSMα1 and PSMα3

Differential fibril morphologies and thermostability determine functional roles of Staphylococcus aureus PSMα1 and PSMα3

Phenol-soluble modulins (PSMs) are virulent peptides secreted by staphylococci that undergo self-assembly into amyloid fibrils. This study focuses on Staphylococcus aureus PSMα1 and PSMα3, which share homologous sequences but exhibit distinct amyloid fibril structures. Upon subjecting PSMα1 to an 80...

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Bibliographic Details
Main Authors: Bader Rayan, Eilon Barnea, Alexander Khokhlov, Alexander Upcher, Meytal Landau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
amyloid
thermostabilily
virulence factor
cytotoxicity
PSMs
fibrillation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184785/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184785/full

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