Differential fibril morphologies and thermostability determine functional roles of Staphylococcus aureus PSMα1 and PSMα3
Phenol-soluble modulins (PSMs) are virulent peptides secreted by staphylococci that undergo self-assembly into amyloid fibrils. This study focuses on Staphylococcus aureus PSMα1 and PSMα3, which share homologous sequences but exhibit distinct amyloid fibril structures. Upon subjecting PSMα1 to an 80...
Main Authors: | Bader Rayan, Eilon Barnea, Alexander Khokhlov, Alexander Upcher, Meytal Landau |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-07-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1184785/full |
Similar Items
-
Beyond One-Trick Ponies: The Multifunctional Marvels of Microbial Functional Amyloids
by: Meytal Landau
Published: (2023-05-01) -
Genotypes of <i>Staphylococcus aureus</i> Clinical Isolates Are Associated with Phenol-Soluble Modulin (PSM) Production
by: Harshad Lade, et al.
Published: (2022-08-01) -
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
by: Lin Jiang, et al.
Published: (2013-07-01) -
Rsp promotes the transcription of virulence factors in an agr-independent manner in Staphylococcus aureus
by: Banghui Liu, et al.
Published: (2020-01-01) -
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
by: Elad Arad, et al.
Published: (2023-12-01)