Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD). The flavonoids rich foods such as green tea,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00155/full |
| _version_ | 1817983730870910976 |
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| author | Muhammad Ayaz Abdul Sadiq Muhammad Junaid Muhammad Junaid Farhat Ullah Muhammad Ovais Muhammad Ovais Ikram Ullah Jawad Ahmed Muhammad Shahid |
| author_facet | Muhammad Ayaz Abdul Sadiq Muhammad Junaid Muhammad Junaid Farhat Ullah Muhammad Ovais Muhammad Ovais Ikram Ullah Jawad Ahmed Muhammad Shahid |
| author_sort | Muhammad Ayaz |
| collection | DOAJ |
| description | Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD). The flavonoids rich foods such as green tea, cocoa, blue berry and other foods improve the various states of cognitive dysfunction, AD and dementia-like pathological alterations in different animal models. The mechanisms of flavonoids have been shown to be mediated through the inhibition of cholinesterases including acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), β-secretase (BACE1), free radicals and modulation of signaling pathways, that are implicated in cognitive and neuroprotective functions. Flavonoids interact with various signaling protein pathways like ERK and PI3-kinase/Akt and modulate their actions, thereby leading to beneficial neuroprotective effects. Moreover, they enhance vascular blood flow and instigate neurogenesis particularly in the hippocampus. Flavonoids also hamper the progression of pathological symptoms of neurodegenerative diseases by inhibiting neuronal apoptosis induced by neurotoxic substances including free radicals and β-amyloid proteins (Aβ). All these protective mechanisms contribute to the maintenance of number, quality of neurons and their synaptic connectivity in the brain. Thus flavonoids can thwart the progression of age-related disorders and can be a potential source for the design and development of new drugs effective in cognitive disorders. |
| first_indexed | 2024-04-13T23:36:48Z |
| format | Article |
| id | doaj.art-13d3468b3dda415d95ada3ee15a953c9 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T23:36:48Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-13d3468b3dda415d95ada3ee15a953c92022-12-22T02:24:43ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-06-011110.3389/fnagi.2019.00155404705Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological DisordersMuhammad Ayaz0Abdul Sadiq1Muhammad Junaid2Muhammad Junaid3Farhat Ullah4Muhammad Ovais5Muhammad Ovais6Ikram Ullah7Jawad Ahmed8Muhammad Shahid9Department of Pharmacy, University of Malakand, Chakdara, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, PakistanDepartment of Pharmacy, University of Swabi, Swabi, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, PakistanUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaSuliman Bin Abdullah Aba-Alkhail Centre for Interdisciplinary Research in Basic Sciences, International Islamic University Islamabad, Islamabad, PakistanInstitute of Basic Medical Sciences (IBMS), Khyber Medical University, Peshawar, PakistanDepartment of Pharmacy, Sarhad University of Science and Information Technology (SUIT), Peshawar, PakistanModern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD). The flavonoids rich foods such as green tea, cocoa, blue berry and other foods improve the various states of cognitive dysfunction, AD and dementia-like pathological alterations in different animal models. The mechanisms of flavonoids have been shown to be mediated through the inhibition of cholinesterases including acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), β-secretase (BACE1), free radicals and modulation of signaling pathways, that are implicated in cognitive and neuroprotective functions. Flavonoids interact with various signaling protein pathways like ERK and PI3-kinase/Akt and modulate their actions, thereby leading to beneficial neuroprotective effects. Moreover, they enhance vascular blood flow and instigate neurogenesis particularly in the hippocampus. Flavonoids also hamper the progression of pathological symptoms of neurodegenerative diseases by inhibiting neuronal apoptosis induced by neurotoxic substances including free radicals and β-amyloid proteins (Aβ). All these protective mechanisms contribute to the maintenance of number, quality of neurons and their synaptic connectivity in the brain. Thus flavonoids can thwart the progression of age-related disorders and can be a potential source for the design and development of new drugs effective in cognitive disorders.https://www.frontiersin.org/article/10.3389/fnagi.2019.00155/fullAlzheimer’s diseasepolyphenolsamyloid betacholinesterasesantioxidantsignaling pathways and cognition |
| spellingShingle | Muhammad Ayaz Abdul Sadiq Muhammad Junaid Muhammad Junaid Farhat Ullah Muhammad Ovais Muhammad Ovais Ikram Ullah Jawad Ahmed Muhammad Shahid Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders Frontiers in Aging Neuroscience Alzheimer’s disease polyphenols amyloid beta cholinesterases antioxidant signaling pathways and cognition |
| title | Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders |
| title_full | Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders |
| title_fullStr | Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders |
| title_full_unstemmed | Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders |
| title_short | Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders |
| title_sort | flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders |
| topic | Alzheimer’s disease polyphenols amyloid beta cholinesterases antioxidant signaling pathways and cognition |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00155/full |
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