Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we analysed the phenotype and activity of NK cells in the blood of COVID-19 patients using flow cytometry, singl...

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Bibliographic Details
Main Authors: Bert Malengier-Devlies, Jessica Filtjens, Kourosh Ahmadzadeh, Bram Boeckx, Jessica Vandenhaute, Amber De Visscher, Eline Bernaerts, Tania Mitera, Cato Jacobs, Lore Vanderbeke, Pierre Van Mol, Yannick Van Herck, Greet Hermans, Philippe Meersseman, Alexander Wilmer, Mieke Gouwy, Abhishek D. Garg, Stephanie Humblet-Baron, Frederik De Smet, Kimberly Martinod, Els Wauters, Paul Proost, Carine Wouters, Georges Leclercq, Diether Lambrechts, Joost Wauters, Patrick Matthys
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
COVID-19
NK cells
cytokines
cytotoxicity
platelet aggregates
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.861251/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.861251/full

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