Somatic BRCA Mutation in a Cholangiocarcinoma Patient for HBOC Syndrome Detection

Somatic BRCA Mutation in a Cholangiocarcinoma Patient for HBOC Syndrome Detection

BRCA-associated hereditary breast and ovarian cancer syndrome (HBOC) is characterized by an increased risk of developing other malignancies including cholangiocarcinoma (CCA). Somatic BRCA mutations have been reported in CCA, but they have yet to be utilized in a proband case to identify HBOC in fam...

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Bibliographic Details
Main Authors: Angelo Virgilio Paradiso, Margherita Patruno, Maria Digennaro, Stefania Tommasi, Brunella Pilato, Antonella Argentiero, Oronzo Brunetti, Nicola Silvestris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
BRCA1
BRCA2
biliary tract cancers
hereditary BRCA cancer
somatic mutations
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01292/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01292/full

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