Potential Use of 3D CORAGRAF-Loaded PDGF-BB in PLGA Microsphere Seeded Mesenchymal Stromal Cells in Enhancing the Repair of Calvaria Critical-Size Bone Defect in Rat Model

Potential Use of 3D CORAGRAF-Loaded PDGF-BB in PLGA Microsphere Seeded Mesenchymal Stromal Cells in Enhancing the Repair of Calvaria Critical-Size Bone Defect in Rat Model

Our previous study evidenced that the 3D CORAGRAF loaded with PLGA microsphere constitutes PDGF-BB can support cell attachment and proliferation and can induce an osteogenic commitment of mesenchymal stromal cells in the in vitro condition. However, how this construct can perform in pathophysiologic...

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Bibliographic Details
Main Authors: Saktiswaren Mohan, Puvanan Karunanithi, Malliga Raman Murali, Khairul Anwar Ayob, Jayaraman Megala, Krishnamurithy Genasan, Tunku Kamarul, Hanumantha Rao Balaji Raghavendran
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Marine Drugs
Subjects:
coral
calvaria
platelet-derived growth factor
microsphere
micro-CT
histology
Online Access:https://www.mdpi.com/1660-3397/20/9/561

Internet

https://www.mdpi.com/1660-3397/20/9/561

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