Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation

Microglia become increasingly dysfunctional with aging and contribute to the onset of neurodegenerative disease (NDs) through defective phagocytosis, attenuated cholesterol efflux, and excessive secretion of pro-inflammatory cytokines. Dysfunctional microglia also accumulate lipid droplets (LDs); ho...

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Bibliographic Details
Main Authors: Bailey A. Loving, Maoping Tang, Mikaela C. Neal, Sachi Gorkhali, Robert Murphy, Robert H. Eckel, Kimberley D. Bruce
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
lipoprotein lipase
PPAR agonists
microglia
neurodegenerative disease
lipid droplet
Online Access:https://www.mdpi.com/2073-4409/10/2/198

Internet

https://www.mdpi.com/2073-4409/10/2/198

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