Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination

Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination

Highlights Leuprolide acetate (50 µg/kg, postnatal day 25–50) suppresses pubertal development in female and male rats. Estrous cyclicity is suppressed during treatment in female rats. Development of male copulatory behavior and sexual motivation is significantly delayed but reaches control levels wi...

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Bibliographic Details
Main Authors: Fay A. Guarraci, Layla Avendano, Megan Kelly, Cleriza Estoesta, Bernard Sencherey, Hannah S. Valdivia, Amanda Gale, Lily Yepez, Jasmine B. Belfield, Kristen M. Carter, Natalie Williams, Andrea C. Gore
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Biology of Sex Differences
Subjects:
GnRH agonist
Partner preference
Sexual motivation
Estrous cycle
Vaginal opening
Preputial separation
Online Access:https://doi.org/10.1186/s13293-022-00485-5

Internet

https://doi.org/10.1186/s13293-022-00485-5

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