CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring

CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring

IntroductionThe leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements, “stereotyped BCRs”. The B-cell receptors (BCRs) on CLL cells are also distinctive in often deriving from autoreactive B lymphocytes,...

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Bibliographic Details
Main Authors: Stefano Vergani, Davide Bagnara, Andreas Agathangelidis, Anita Kar Yun Ng, Gerardo Ferrer, Andrea N. Mazzarello, Florencia Palacios, Sophia Yancopoulos, Xiao-Jie Yan, Jaqueline C. Barrientos, Kanti R. Rai, Kostas Stamatopoulos, Nicholas Chiorazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
CLL (chronic lymphocytic leukemia)
B cell development and differentiation
B cell repertoire
stereotyped antigen receptors
VDJ sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1112879/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1112879/full

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