Lipoplexes to Deliver Oligonucleotides in Gram-Positive and Gram-Negative Bacteria: Towards Treatment of Blood Infections

Lipoplexes to Deliver Oligonucleotides in Gram-Positive and Gram-Negative Bacteria: Towards Treatment of Blood Infections

Bacterial resistance to antibiotics threatens the ability to treat life-threatening bloodstream infections. Oligonucleotides (ONs) composed of nucleic acid mimics (NAMs) able to inhibit essential genes can become an alternative to traditional antibiotics, as long as they are safely transported in hu...

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Bibliographic Details
Main Authors: Sara Pereira, Rita Sobral Santos, Luís Moreira, Nuno Guimarães, Mariana Gomes, Heyang Zhang, Katrien Remaut, Kevin Braeckmans, Stefaan De Smedt, Nuno Filipe Azevedo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
bacteria
bloodstream infections
liposomes
locked nucleic acid
oligonucleotides
Online Access:https://www.mdpi.com/1999-4923/13/7/989

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https://www.mdpi.com/1999-4923/13/7/989

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