c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity

c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity

Abstract During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk for replication-induced DNA damage. Here, we find t...

Full description

Bibliographic Details
Main Authors: Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42765-7

Internet

https://doi.org/10.1038/s41467-023-42765-7

Similar Items