Establishment of in vitro Calibration Curve for 60Co-γ-rays Induced Phospho-53BP1 Foci, Rapid Biodosimetry and Initial Triage, and Comparative Evaluations With γH2AX and Cytogenetic Assays

Establishment of in vitro Calibration Curve for 60Co-γ-rays Induced Phospho-53BP1 Foci, Rapid Biodosimetry and Initial Triage, and Comparative Evaluations With γH2AX and Cytogenetic Assays

A rapid and reliable method for biodosimetry of populations exposed to ionizing radiation in the event of an incident or accident is crucial for initial triage and medical attention. DNA-double strand breaks (DSBs) are indicative of radiation exposure, and DSB-repair proteins (53BP1, γH2AX, ATM, etc...

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Bibliographic Details
Main Authors: Rajesh Kumar Chaurasia, Kapil B. Shirsath, Utkarsha N. Desai, Nagesh N. Bhat, B. K. Sapra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Public Health
Subjects:
53BP1 foci
γH2AX foci
dicentrics and reciprocal translocations
rapid biodosimetry
radiation induced DNA-DSB detection
colocalization of γH2AX and 53BP1 foci
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2022.845200/full

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https://www.frontiersin.org/articles/10.3389/fpubh.2022.845200/full

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