Establishment of in vitro Calibration Curve for 60Co-γ-rays Induced Phospho-53BP1 Foci, Rapid Biodosimetry and Initial Triage, and Comparative Evaluations With γH2AX and Cytogenetic Assays

Establishment of in vitro Calibration Curve for 60Co-γ-rays Induced Phospho-53BP1 Foci, Rapid Biodosimetry and Initial Triage, and Comparative Evaluations With γH2AX and Cytogenetic Assays

A rapid and reliable method for biodosimetry of populations exposed to ionizing radiation in the event of an incident or accident is crucial for initial triage and medical attention. DNA-double strand breaks (DSBs) are indicative of radiation exposure, and DSB-repair proteins (53BP1, γH2AX, ATM, etc...

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Bibliographic Details
Main Authors:	Rajesh Kumar Chaurasia, Kapil B. Shirsath, Utkarsha N. Desai, Nagesh N. Bhat, B. K. Sapra
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Public Health
Subjects:	53BP1 foci γH2AX foci dicentrics and reciprocal translocations rapid biodosimetry radiation induced DNA-DSB detection colocalization of γH2AX and 53BP1 foci
Online Access:	https://www.frontiersin.org/articles/10.3389/fpubh.2022.845200/full

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