Bulged and Canonical G-Quadruplex Conformations Determine NDPK Binding Specificity

Guanine-rich DNA strands can adopt tertiary structures known as G-quadruplexes (G4s) that form when Hoogsteen base-paired guanines assemble as planar stacks, stabilized by a central cation like K<sup>+</sup>. In this study, we investigated the conformational heterogeneity of a G-rich seq...

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Bibliographic Details
Main Authors: Mykhailo Kopylov, Trevia M. Jackson, M. Elizabeth Stroupe
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/10/1988