Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back Pain

Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back Pain

Chronic back pain (CBP) is a complex heritable trait and a major cause of disability worldwide. We developed and validated a genome-wide polygenic risk score (PRS) for CBP using a large-scale GWAS based on UK Biobank participants of European ancestry (N = 265,000). The PRS showed poor overall predic...

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Bibliographic Details
Main Authors: Yakov A. Tsepilov, Elizaveta E. Elgaeva, Arina V. Nostaeva, Roger Compte, Ivan A. Kuznetsov, Lennart C. Karssen, Maxim B. Freidin, Pradeep Suri, Frances M. K. Williams, Yurii S. Aulchenko
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Personalized Medicine
Subjects:
low back pain
GWAS
polygenic risk score
chronic back pain
Online Access:https://www.mdpi.com/2075-4426/13/6/977

Internet

https://www.mdpi.com/2075-4426/13/6/977

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