Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Abstract The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration of normal ribosomal activity. While the role of PPP1R...

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Bibliographic Details
Main Authors: Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00769-7

Internet

https://doi.org/10.1038/s41598-021-00769-7

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