PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers. Here, using an integrative approach, we have dissected the metabolic fingerprints of lung adenocarcinomas, and we show...

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Bibliographic Details
Main Authors: Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin Vakifahmetoglu-Norberg, Erik Norberg
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
tumor metabolism
metabolic heterogeneity
lung cancer
PHGDH
serine
DNA damage
pyrimidines
purines
lung adenocarcinoma
metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307246

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http://www.sciencedirect.com/science/article/pii/S2211124717307246

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