Generation of Mouse Model of Hemophilia A by Introducing Novel Mutations, Using CRISPR/Nickase Gene Targeting System
Developing mouse models of hemophilia A has been shown to facilitate in vivo studies to explore the probablemechanism(s) underlying the disease and to examine the efficiency of the relevant potential therapeutics. This studyaimed to knockout (KO) the coagulation factor viii (fviii) gene in NMRI mice...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2023-09-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://www.celljournal.org/article_705505_27aeb300fbfc88bb89c5dce7a7ca5d3a.pdf |